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ea0099p6 | Adrenal and Cardiovascular Endocrinology | ECE2024

The differential impact of oral classic and 11-oxygenated androgen precursor administration on downstream androgen metabolism and insulin sensitivity in women with polycystic ovary syndrome

McDonnell Tara , Cussen Leanne , Miller Clare , Jacob Benson , Taylor Angela , Arlt Wiebke , McIlroy Marie , Heinz-Storbech Karl , Hodson Leanne , Tomlinson Jeremy , Sherlock Mark , O'Reilly Michael W.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Androgen excess is a cardinal biochemical feature of PCOS and correlates closely with markers of insulin resistance. 11-oxygenated androgens are the predominant androgens in PCOS, however their relationship with metabolic dysfunction is unclear. The aims of this study were (i) to evaluate the downstream impact on androgen metabolism of oral classic and 11-oxygenated precursor administration and (i...

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The differential impact of oral classic and 11-oxygenated androgen precursor administration on downstream androgen metabolism and insulin sensitivity in women with polycystic ovary syndrome

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